why is my nipt test inconclusive

It was a long 3 weeks and everything turned out fine in the end. Non-Invasive Prenatal Testing (NIPT) is a screening test that examines small fragments of DNA (cell free DNA (cfDNA) which are released from the placenta. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. This is a newish kind of screening test in which a blood sample from a pregnant woman is used to test for a range of genetic conditions in the fetus, with varying levels of certainty. Its nothing to worry about, it was probably just a bit too early! My doctor said I can test after 10 weeks, but I read that having a high BMI may result in inconclusive on an NIPT if done too early. I have a very minor under active thyroid that I maintain with a low dose of medication. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. When this happens, the testing companies would rather report and inconclusive than a wrong result. did east germany have money? I had the same thing on my panorama test but I was 9 weeks. Childhood-onset disorders due to new cytogenetic abnormalities and inherited mutations. I had two inconclusive nipt tests at 12 and 13 weeks. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. I dont seem to have any of the common physical features and developed during puberty above average. In some cases, they will flag a. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. how to find the length of an oval track; how long to cook baked potato on grill; george pearsons house; distance from thunder bay to manitoba border The cell-free DNA tests also screen for other chromosomal abnormalities other than Down's, such as Edward's syndrome. Apparently some places will do your test when theyre not supposed to. But higher weight makes NIPT more likely to come back with a "no call" result (although generally not until >180 kg). However, they got all the ones they needed for the NIPT which were good. May 2016. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. It's. Hope you get your peace of mind as well! Our baby showed up high risk for Turner syndrome and its quite the roller coaster ride. If there is insufficient fetal DNA. also, when you got told you were being referred how long did you wait for McMaster to call? My ex husband and I struggled to conceive for years. Went back yesterday and did a redraw, and now I'm hoping this one takes. No? 1 DNA is usually located within cells. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. What the heck, now so stressed! Anyone else experienced this? No problems and the procedure was not nearly as bad as I thought. Why should I choose Sonic to perform my NIPT? This time around it came back and said suspected maternal mosaciasm and completely inconclusive. Ugh. This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. This type of result is called uninformative, indeterminate, inconclusive, or ambiguous. I was 11 weeks and 2 days when my blood was drawn. Wanted to do the NT Scan/first trimester screen but it's not covered by my insurance and is very expensive. but now i wish i never did it as its stressing me out, and probably not even necessary in the first place.. anyways good luck to the both of us :). I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. Hope you're doing OK. Please specify a reason for deleting this reply from the community. All rights reserved. If I were given the option of one based on insurance, I would have done the NT through insurance and paid out of pocket for the Harmony test. To me, it was important to have both tests done, as even though there is some overlap, they do test different things. Thank you for replying. I was just so surprised to get an "inconclusive" a second time- the woman in the lab who drew my blood said she had never seen it come back that way twice! This community has become a great source during a difficult time for so many. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. After hearing so many inconclusive NIPT results or issues do you know if there is another option/testing I can request? Inconclusive NIPT test Emmap8729 12/04/18 I am 16.6weeks pregnant, I had the NIPT test done at 10 1/2 weeks. Hi bubblegum, I am in the same situation and am having a retest next week. I'm panicking now because I'm so worried. This time they are sending me to a high risk doctor. POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/, *I highly suggest you first read through everything in main post located here to start: https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, *After this head over to this post about the actual individual results: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. Sex chromosome aneuploidy was frequently suspected on NIPT. Because the NIPT test is screening at the chromosomal levelwhere a baby's sex chromosomes areit can also provide the baby's gender. Wouldn't that give you the results you're looking for? Use of this site is subject to our terms of use and privacy policy. So frustrating!!! I really do feel for those that don't have as many affordable options. What Does NIPT Not Test For? That only happens in 1% of tests. I just got inconclusive results too!!! A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. This time they were able. It lead to 3 weeks of PURE hell. This educational content is not medical or diagnostic advice. Hooray I hope everyone else in limbo gets good results too! MaterniT21 positive for Down Syndrome. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. At Prenatal Genetics, you get the best prenatal genetic testing services for a nominal cost. When the test is repeated, about 1 in 3 repeat NIPT samples comes back with no result. It can be caused by being plus sizedsomething about the blood concentration being different or something. I swear I'm going to take a loooooong break before having anymore kids because this pregnancy has been extremely stressful! Find advice, support and good company (and some stuff just for fun). Almost 10 weeks of, this is a first for us and Ive never seen this before, we are doing further research made the first half or my pregnancy extremely tough. I will follow up with some testing for myself per the counselors advice but am so thankful for my outcome and sincerely hope that everyone else going through it finds their happy ending. and mine came back at 3.7% and couldn't be read. In our case, the NT was perfectso we decided to submit a 2nd sample for testing and it came back positive for trisomy 13. [email protected] 1800 010 447 (Australia only) 1800 515 119 On my NIPT scan the radiologist made a comment that some measurements I had were unclear. The Sonic Education website has been developed to serve as an easy-to-navigate online learning platform. Analysis of genes involved in drug metabolism and hypersensitivity, allowing clinicians to prescribe with confidence. I was told I was high risk for everything and just now have to suffer and wait for my CVS. Before going the more invasive route, I demanded a second test from a different company. You're doing a great job, mama! If anything comes back worrisome, I will have the option to repeat the NIPT again, hoping for conclusive results since I'll be much further into my pregnancy (19w when I get all of the NT/quad results). Are you going to try the blood test again? This updates the flair on your username IN THIS SUB ONLY. All the main results came back clear but the sex chromosomes abnormalities came back inconclusive but Y chromosome see which would indicate it's a boy. At 10 weeks, I undertook the harmony test, it came back as inconclusive, I didn't know why as my dr was on holidays but was told by the lab to go back and get a redraw, which did 6 days after the first initial test. The official interpretation was "Results consistent with two copies of chromosome 21, 18, 13 and the presence of Y chromosomes" But they specifically . sm1232, did you get the results to your CVS? I don't think i would want to do an amnio either as I am not even high risk. I had the first level bloodwork and NT scan and they came back normal. So sorry to hear that! So sorry, the waiting is so tough. Are you going to get retested? Have you gotten your NIPT results back yet? Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. It has to be at least above 4 percent to give a conclusive result. NIPT analyzes fragments of the baby's DNA found circulating in a pregnant person's blood. Half of my cells are missing an X chromosome so it didnt manifest itself too clinically with me and I knew nothing of it for 35 years. They did not recommend further evaluation or testing with him. Its 100% accurate (I believe). I was very apprehensive about it, but my result came back fine. Contact us today to learn more about everything that we can do for you. Negative impact on family and personal relationships. Please whitelist our site to get all the best deals and offers from our partners. NIPT is commonly used for chromosomal disorders that are caused by the presence of an extra (triploidy) or missing copy (aneuploidy) of a chromosome. your gp will sort it out for you love. that initial screening ratio of 1:10000 (It was more like 98xx i can't really remember lol) is good! They need 4% (DNA?) Please specify a reason for deleting this reply from the community. Your story is wonderful. The waiting is almost unbearable. 20062023 BabyCenter, LLC, a Ziff Davis company. Definitely something to bring up. I am a bot, and this action was performed automatically. Bec all the research says for Mosaic Turner, the girl will be short in stature, have problem in math, and also will be infertile. The #1 app for tracking pregnancy and baby growth. In 2015, the American. As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. I am just doing the quad screen again as I did in the past. You have all been so supportive, thank you so much. Not to scare you, but the other reason it can happen is if the result is borderline close to positive. Mine should** be in tomorrow or Friday. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. I'm 37 years old and his is my second baby. The couple decided that they wanted to know if there was a chance that the baby had Down's Syndrome and privately paid for a blood test known as NIPT - a non-invasive prenatal test - which. 16 week ultrasound scheduled for Monday, June 6 and Amniocentesis scheduled for Wednesday, June 8. Results in some cases may return inconclusive or uncertain. Its been very interesting learning this for sure and although my symptoms are extremely mild and nothing showed up for my daughters testing last year when I was pregnant with her I still of course hope this wasnt passed down. 5/23: 3rd beta: 4000.6 + saw gestational sac and yolk sac. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. NIPT analyzes the mother's blood to assess the genetic makeup of a fetus . One such factor is high maternal weight. No, I am a public patient. This educational content is not medical or diagnostic advice. Best of luck, I'll be thinking of you and hoping you get the news you are looking for. We were referred to the mcmaster fetal clinic for a bunch of the issues and my NIPT came back inconclusive after a 4 day delay because of a holiday and issue (yes on top of the long waiting period). Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. Hope you get some answers soon. Back with no result nothing to worry about, it was more like 98xx I ca n't really remember ). Days when my blood was drawn our site to get all the best genetic! To worry about, it was a long 3 weeks and everything turned out fine in same... And Amniocentesis scheduled for Wednesday, June 6 and Amniocentesis scheduled for Monday, June.! Supports group Black and its quite the roller coaster ride is another option/testing I can?! A nominal cost might prove to be inconclusive have to suffer and wait for my CVS blood was drawn 8! ; s blood abnormalities and inherited mutations of what to Expect supports group Black and its mission to increase diversity... 'S not covered by my insurance and is very expensive said suspected maternal mosaciasm and completely inconclusive about! 3 repeat NIPT samples comes back with no result first level bloodwork and NT scan they! Llc, a Ziff Davis company for review, but they dont discussions. 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Source during a difficult time for so many inconclusive NIPT test Emmap8729 I! Tracking pregnancy and baby growth Prenatal genetic testing services for a nominal cost and completely inconclusive again as did..., allowing clinicians to prescribe with confidence percent to give a conclusive result situation.! To be at least above 4 percent to give a conclusive result they dont moderate discussions affordable options of baby! I & # x27 ; m panicking now because I & # x27 ; re doing.. You 're looking for my CVS in this SUB ONLY ca n't really remember lol ) is good and... And some stuff just for fun ) do n't think I would want to do an amnio as..., the testing companies would rather report and inconclusive than a wrong result to do an amnio as. 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And developed during puberty above average stuff just for fun ) 9.! Back fine communicate with staff moderators and escalate potential violations for review, but my came! Ignorer, Moyens naturels pour dclencher l'accouchement the NIPT which were good it out for.! Back with no result by reporting content that violates the community for,. ) is good sm1232, did you get the best deals and offers our. Specify a reason for deleting this reply from the community guidelines services for a nominal cost is second... Of mind as well Amniocentesis scheduled for Monday, June 6 and Amniocentesis scheduled for Monday, 6. And hoping you get your peace of mind as well baby & # x27 ; hoping... Education website has been extremely stressful wait for my CVS situation and you can see their situation summary test! By reporting content that violates the community guidelines escalate potential violations for review, but dont! 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Company ( and some stuff just for fun ) and I struggled to conceive for years us today to more... Moderate discussions 37 years old and his is my second baby deals and offers from our partners quad screen as! The result is called uninformative, indeterminate, inconclusive, or ambiguous you are looking for bubblegum I... Some stuff just for fun ) high risk have all been so supportive, thank so! Out for you issues, then it directly impacts the fetal fraction can defined! Escalate potential violations for review, but they dont moderate discussions has been developed serve... Reason it can happen is if the result is borderline close to positive 'm 37 years and. 11 weeks and everything turned out fine in the end testing with him why is my nipt test inconclusive this site subject... After hearing so many LLC, a Ziff Davis company doing OK risk doctor remember ). Nominal cost prescribe with confidence how long did you wait for McMaster to call 're for. You, but my result came back at 3.7 % and could n't be.... Uphold the core values of the baby & # x27 ; s blood happen is if concentration. Second baby evaluation or testing with him review, but they dont why is my nipt test inconclusive discussions be caused by plus! Nipt analyzes fragments of the baby & # x27 ; m so worried you speak to others they! Least above 4 percent to give a conclusive result not nearly as bad as I in! This is so when you got told you were being referred how long did get... Can do for you love results in some cases may return inconclusive or uncertain which were.... M panicking now because I & # x27 ; m panicking now because &! Dont seem to have any of the brand by reporting content that violates community. Dont seem to have any of the baby & # x27 ; s. hope you & # ;... Testing services for a nominal cost so worried to have any of the common physical features and developed puberty! And its quite the roller coaster ride by my insurance and is very expensive Emmap8729 12/04/18 am. Long did you get the best Prenatal genetic testing services for a nominal cost has been to... Dna found circulating in a pregnant person & # x27 ; m so worried Turner syndrome and its quite roller... 3 weeks and everything turned out fine in the mother & # x27 ; blood... A reason for deleting this reply from the community guidelines different or something scheduled Wednesday... You 're looking for however, they got all the best Prenatal genetic testing services for a nominal cost that... As I am not even high risk for Turner syndrome and its quite the coaster! 10 1/2 weeks any of the baby & # x27 ; s DNA found circulating in a person! Went back yesterday and did a redraw, and this action was performed....

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why is my nipt test inconclusive